Association of Killer Cell Immunoglobulin-Like Receptor Genes with Pandemic Influenza A (H1N1)pdm09 Infection in Critically III Macedonian Patients
Identifieur interne : 000A04 ( Main/Exploration ); précédent : 000A03; suivant : 000A05Association of Killer Cell Immunoglobulin-Like Receptor Genes with Pandemic Influenza A (H1N1)pdm09 Infection in Critically III Macedonian Patients
Auteurs : Aleksandar Petlichkovski ; Zvonko Milenkovic ; Eli Djulejic [Serbie] ; Bisera Jefremovska ; Haris Babacic ; Ljubomir Ivanovski ; Irena Kondova Topuzovska ; Katerina Spasovska ; Mirko SpiroskiSource :
- Macedonian Journal of Medical Sciences [ 1857-5749 ] ; 2012-11-01.
Abstract
Background: Infection by the pandemic influenza A (H1N1)pdm09 virus results in significant pathology disease in many cases in different populations worldwide. The natural killer (NK) cells are among the major effectors important in early innate immune responses to viral infections, interacting with host cells through their activating or inhibiting receptors. Aim: The aim of this study was to analyze Killer Ig-Like Receptor (KIR) gene polymorphisms in critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. Material and Methods: The studied sample consists of 63 critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. The population genetics analysis package, Arlequin, was used for analysis of the data. Results: We found that all 16 KIR genes were observed in the studied individuals and framework genes (KIR3DL3, KIR3DP1, KIR2DL4, and KIR3DL2) were present in all individuals. The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that KIR genes present a wide range of linkage disequilibrium. Comparison of KIR gene frequencies between critically ill H1N1/09 Macedonian patients and healthy subjects reveals statistically significant difference for frequency of KIR2DL1 (F=1 in the patients group, and 0.94 in the control group, p=0.045). Conclusion: We did not found any significant association of all 16 KIR genes or KIR genotypes with critically ill (H1N1)pdm09 Macedonian patients, except for the KIR2DL1.
Url:
- https://api.istex.fr/document/5BD07C6FC8A997FE056D02C36D195229D8AB7F16/fulltext/pdf
- https://api.istex.fr/document/A9CE1F9D0FF59176FBB4B968BE48566A3CD9107B/fulltext/pdf
DOI: 10.2478/mjms.1857-5773.2012.0265
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000C31
- to stream Istex, to step Curation: 000C29
- to stream Istex, to step Checkpoint: 000618
- to stream Main, to step Merge: 000A06
- to stream Istex, to step Corpus: 000C32
- to stream Istex, to step Curation: 000C30
- to stream Istex, to step Checkpoint: 000617
- to stream Main, to step Merge: 000A05
- to stream Main, to step Curation: 000A04
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of Killer Cell Immunoglobulin-Like Receptor Genes with Pandemic Influenza A (H1N1)pdm09 Infection in Critically III Macedonian Patients</title>
<author><name sortKey="Petlichkovski, Aleksandar" sort="Petlichkovski, Aleksandar" uniqKey="Petlichkovski A" first="Aleksandar" last="Petlichkovski">Aleksandar Petlichkovski</name>
</author>
<author><name sortKey="Milenkovic, Zvonko" sort="Milenkovic, Zvonko" uniqKey="Milenkovic Z" first="Zvonko" last="Milenkovic">Zvonko Milenkovic</name>
</author>
<author><name sortKey="Djulejic, Eli" sort="Djulejic, Eli" uniqKey="Djulejic E" first="Eli" last="Djulejic">Eli Djulejic</name>
</author>
<author><name sortKey="Jefremovska, Bisera" sort="Jefremovska, Bisera" uniqKey="Jefremovska B" first="Bisera" last="Jefremovska">Bisera Jefremovska</name>
</author>
<author><name sortKey="Babacic, Haris" sort="Babacic, Haris" uniqKey="Babacic H" first="Haris" last="Babacic">Haris Babacic</name>
</author>
<author><name sortKey="Ivanovski, Ljubomir" sort="Ivanovski, Ljubomir" uniqKey="Ivanovski L" first="Ljubomir" last="Ivanovski">Ljubomir Ivanovski</name>
</author>
<author><name sortKey="Kondova Topuzovska, Irena" sort="Kondova Topuzovska, Irena" uniqKey="Kondova Topuzovska I" first="Irena" last="Kondova Topuzovska">Irena Kondova Topuzovska</name>
</author>
<author><name sortKey="Spasovska, Katerina" sort="Spasovska, Katerina" uniqKey="Spasovska K" first="Katerina" last="Spasovska">Katerina Spasovska</name>
</author>
<author><name sortKey="Spiroski, Mirko" sort="Spiroski, Mirko" uniqKey="Spiroski M" first="Mirko" last="Spiroski">Mirko Spiroski</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:5BD07C6FC8A997FE056D02C36D195229D8AB7F16</idno>
<date when="2012" year="2012">2012</date>
<idno type="doi">10.2478/mjms.1857-5773.2012.0265</idno>
<idno type="url">https://api.istex.fr/document/5BD07C6FC8A997FE056D02C36D195229D8AB7F16/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C31</idno>
<idno type="wicri:Area/Istex/Curation">000C29</idno>
<idno type="wicri:Area/Istex/Checkpoint">000618</idno>
<idno type="wicri:doubleKey">1857-5749:2012:Petlichkovski A:association:of:killer</idno>
<idno type="wicri:Area/Main/Merge">000A06</idno>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:A9CE1F9D0FF59176FBB4B968BE48566A3CD9107B</idno>
<idno type="url">https://api.istex.fr/document/A9CE1F9D0FF59176FBB4B968BE48566A3CD9107B/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C32</idno>
<idno type="wicri:Area/Istex/Curation">000C30</idno>
<idno type="wicri:Area/Istex/Checkpoint">000617</idno>
<idno type="wicri:doubleKey">1857-5749:2012:Petlichkovski A:association:of:killer</idno>
<idno type="wicri:Area/Main/Merge">000A05</idno>
<idno type="wicri:Area/Main/Curation">000A04</idno>
<idno type="wicri:Area/Main/Exploration">000A04</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Association of Killer Cell Immunoglobulin-Like Receptor Genes with Pandemic Influenza A (H1N1)pdm09 Infection in Critically III Macedonian Patients</title>
<author><name sortKey="Petlichkovski, Aleksandar" sort="Petlichkovski, Aleksandar" uniqKey="Petlichkovski A" first="Aleksandar" last="Petlichkovski">Aleksandar Petlichkovski</name>
<affiliation><wicri:noCountry code="subField">Macedonia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Milenkovic, Zvonko" sort="Milenkovic, Zvonko" uniqKey="Milenkovic Z" first="Zvonko" last="Milenkovic">Zvonko Milenkovic</name>
<affiliation><wicri:noCountry code="subField">Macedonia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Djulejic, Eli" sort="Djulejic, Eli" uniqKey="Djulejic E" first="Eli" last="Djulejic">Eli Djulejic</name>
<affiliation wicri:level="1"><country xml:lang="fr">Serbie</country>
<wicri:regionArea>Quintiles, Belgrade</wicri:regionArea>
<wicri:noRegion>Belgrade</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jefremovska, Bisera" sort="Jefremovska, Bisera" uniqKey="Jefremovska B" first="Bisera" last="Jefremovska">Bisera Jefremovska</name>
<affiliation><wicri:noCountry code="subField">Macedonia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Babacic, Haris" sort="Babacic, Haris" uniqKey="Babacic H" first="Haris" last="Babacic">Haris Babacic</name>
<affiliation><wicri:noCountry code="subField">Macedonia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ivanovski, Ljubomir" sort="Ivanovski, Ljubomir" uniqKey="Ivanovski L" first="Ljubomir" last="Ivanovski">Ljubomir Ivanovski</name>
<affiliation><wicri:noCountry code="subField">Macedonia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kondova Topuzovska, Irena" sort="Kondova Topuzovska, Irena" uniqKey="Kondova Topuzovska I" first="Irena" last="Kondova Topuzovska">Irena Kondova Topuzovska</name>
<affiliation><wicri:noCountry code="subField">Macedonia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Spasovska, Katerina" sort="Spasovska, Katerina" uniqKey="Spasovska K" first="Katerina" last="Spasovska">Katerina Spasovska</name>
<affiliation><wicri:noCountry code="subField">Macedonia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Spiroski, Mirko" sort="Spiroski, Mirko" uniqKey="Spiroski M" first="Mirko" last="Spiroski">Mirko Spiroski</name>
<affiliation><wicri:noCountry code="subField">Macedonia</wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Macedonian Journal of Medical Sciences</title>
<idno type="ISSN">1857-5749</idno>
<idno type="eISSN">1857-5773</idno>
<imprint><publisher>Versita</publisher>
<date type="published" when="2012-11-01">2012-11-01</date>
<biblScope unit="volume">5</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="288">288</biblScope>
<biblScope unit="page" to="295">295</biblScope>
</imprint>
<idno type="ISSN">1857-5749</idno>
</series>
<idno type="istex">5BD07C6FC8A997FE056D02C36D195229D8AB7F16</idno>
<idno type="DOI">10.2478/mjms.1857-5773.2012.0265</idno>
<idno type="ArticleID">mjms.1857-5773.2012.0265</idno>
<idno type="pdf">mjms.1857-5773.2012.0265.pdf</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1857-5749</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: Infection by the pandemic influenza A (H1N1)pdm09 virus results in significant pathology disease in many cases in different populations worldwide. The natural killer (NK) cells are among the major effectors important in early innate immune responses to viral infections, interacting with host cells through their activating or inhibiting receptors. Aim: The aim of this study was to analyze Killer Ig-Like Receptor (KIR) gene polymorphisms in critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. Material and Methods: The studied sample consists of 63 critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. The population genetics analysis package, Arlequin, was used for analysis of the data. Results: We found that all 16 KIR genes were observed in the studied individuals and framework genes (KIR3DL3, KIR3DP1, KIR2DL4, and KIR3DL2) were present in all individuals. The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that KIR genes present a wide range of linkage disequilibrium. Comparison of KIR gene frequencies between critically ill H1N1/09 Macedonian patients and healthy subjects reveals statistically significant difference for frequency of KIR2DL1 (F=1 in the patients group, and 0.94 in the control group, p=0.045). Conclusion: We did not found any significant association of all 16 KIR genes or KIR genotypes with critically ill (H1N1)pdm09 Macedonian patients, except for the KIR2DL1.</div>
</front>
</TEI>
<affiliations><list><country><li>Serbie</li>
</country>
</list>
<tree><noCountry><name sortKey="Babacic, Haris" sort="Babacic, Haris" uniqKey="Babacic H" first="Haris" last="Babacic">Haris Babacic</name>
<name sortKey="Ivanovski, Ljubomir" sort="Ivanovski, Ljubomir" uniqKey="Ivanovski L" first="Ljubomir" last="Ivanovski">Ljubomir Ivanovski</name>
<name sortKey="Jefremovska, Bisera" sort="Jefremovska, Bisera" uniqKey="Jefremovska B" first="Bisera" last="Jefremovska">Bisera Jefremovska</name>
<name sortKey="Kondova Topuzovska, Irena" sort="Kondova Topuzovska, Irena" uniqKey="Kondova Topuzovska I" first="Irena" last="Kondova Topuzovska">Irena Kondova Topuzovska</name>
<name sortKey="Milenkovic, Zvonko" sort="Milenkovic, Zvonko" uniqKey="Milenkovic Z" first="Zvonko" last="Milenkovic">Zvonko Milenkovic</name>
<name sortKey="Petlichkovski, Aleksandar" sort="Petlichkovski, Aleksandar" uniqKey="Petlichkovski A" first="Aleksandar" last="Petlichkovski">Aleksandar Petlichkovski</name>
<name sortKey="Spasovska, Katerina" sort="Spasovska, Katerina" uniqKey="Spasovska K" first="Katerina" last="Spasovska">Katerina Spasovska</name>
<name sortKey="Spiroski, Mirko" sort="Spiroski, Mirko" uniqKey="Spiroski M" first="Mirko" last="Spiroski">Mirko Spiroski</name>
</noCountry>
<country name="Serbie"><noRegion><name sortKey="Djulejic, Eli" sort="Djulejic, Eli" uniqKey="Djulejic E" first="Eli" last="Djulejic">Eli Djulejic</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Belgique/explor/OpenAccessBelV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A04 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A04 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Belgique |area= OpenAccessBelV2 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:5BD07C6FC8A997FE056D02C36D195229D8AB7F16 |texte= Association of Killer Cell Immunoglobulin-Like Receptor Genes with Pandemic Influenza A (H1N1)pdm09 Infection in Critically III Macedonian Patients }}
This area was generated with Dilib version V0.6.25. |